Hydroxychloroquine Sulfate

A to Z Drug Facts

Hydroxychloroquine Sulfate

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(high-drox-ee-KLOR-oh-kwin SULL-fate)
Plaquenil Sulfate
Class: Anti-infective/Antimalarial; Antirheumatic

 Action May interfere with parasitic nucleoprotein (DNA/RNA) synthesis and parasite growth or cause lysis of parasite or infected erythrocytes. In rheumatoid arthritis, may suppress formation of antigens responsible for symptom-producing hypersensitivity reactions.

 Indications Prophylaxis and treatment of acute attacks of malaria due to Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, and susceptible strains of Plasmodium falciparum. Treatment of chronic discoid and systemic lupus erythematosus (SLE) and acute or chronic rheumatoid arthritis in patients not responding to other therapies.

 Contraindications Retinal or visual field changes caused by any 4-aminoquinoline compound; hypersensitivity to 4-aminoquinoline compounds; long-term therapy in children.

 Route/Dosage

Suppression of Malaria

ADULTS: PO 400 mg (310 mg of base) weekly on same day each week. CHILDREN: PO 5 mg/kg of base weekly on same day each week, up to maximum of 400 mg (310 mg of base). Begin 1 to 2 weeks prior to exposure; continue for 8 weeks after leaving area.

Acute Attack of Malaria

ADULTS: Initial dose PO 800 mg (620 mg of base). CHILDREN: Initial dose PO 10 mg/kg (base), up to adult dose; give half of initial dose 6 hours later and on days 2 and 3.

Rheumatoid Arthritis

ADULTS: Initially PO 400 to 600 mg/day (310 to 465 mg of base) with food or milk. Maintenance: After good response (usually 4 to 12 weeks), reduce dosage by 50% and continue at PO 200 to 400 mg/day (155 to 310 mg of base). CHILDREN: Although experience with hydroxychloroquine in children for rheumatoid arthritis or lupus erythematosus is limited, its use may be warranted in some cases. A dose of 3 to 5 mg/kg/day, up to a maximum of 400 mg/day (given once or twice daily) has been recommended. Do not exceed a dose of 7 mg/kg/day.

Lupus Erythematosus

ADULTS: Initially PO 400 mg/day or bid. For prolonged therapy, reduce to PO 200 to 400 mg/day (155 to 310 mg of base).

 Interactions

Digoxin: May increase serum digoxin levels. Hepatotoxic drugs: May increase potential for hepatotoxicity.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Hypotension; ECG changes. CNS: Headache; irritability; nervousness; emotional changes; nightmares; psychosis; dizziness; vertigo; nystagmus; nerve deafness; convulsions; ataxia. DERM: Bleaching of hair; alopecia; pruritus; skin and mucosal pigmentation; skin eruptions; exacerbation of psoriasis. EENT: Disturbance of accommodation with blurred vision; transient corneal edema; corneal opacities; decreased corneal sensitivity; retinal edema; retinal atrophy; abnormal retinal pigmentation; loss of retinal reflexes; optic disc pallor and atrophy; scotoma; retinopathy; tinnitus. GI: Anorexia; nausea; vomiting; diarrhea; abdominal cramps. HEMA: Aplastic anemia; agranulocytosis; leukopenia; thrombocytopenia; hemolysis in G-6-PD deficiency; exacerbation of porphyria. META: Weight loss. OTHER: Immunoblastic lymphadenopathy; extraocular muscle palsies; skeletal muscle weakness; absent or hypoactive deep tendon reflexes.

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Deaths have occurred following accidental ingestion of relatively small doses. Do not exceed recommended doses for children with malaria. Not indicated for juvenile rheumatoid arthritis. Special risk patients: May exacerbate psoriasis, porphyria, or other dermatitis; may cause hemolysis in patients with G-6-PD deficiency. Renal/Hepatic disease or alcoholism: May increase risk of hepatotoxicity in these conditions. Muscular weakness: If weakness occurs, discontinue. Ophthalmic effects: Irreversible retinal damage with long-term hydroxychloroquine therapy has been observed.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Headache, drowsiness, visual disturbances, cardiovascular collapse, convulsions, respiratory and cardiac arrest, bradycardia, ventricular fibrillation

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts